AI-Gating Patents
AI-Gating Photomodulation
An AI-controlled photonic system that performs therapeutic photomodulation and reflective optical diagnostics, including OCT, OCTA, near-infrared reflectance, and fundus autofluorescence, is described here. The system incorporates an AI Predictive Gating module that identifies optimal temporal windows for energy delivery or data acquisition based on reflectance dynamics, retinal motion, physiologic parameters, mitochondrial biomarkers, and image-quality metrics. By synchronizing photonic emission and diagnostic capture to predicted physiologic states, the system improves diagnostic fidelity, enhances therapeutic precision, and enables earlier detection of degenerative, inflammatory, and pharmacologic retinal injury.
AI-Gating and Photonic Control
A computerized system implements an AI-Gating authorization layer that functions as an execution interlock for digital actions. The AI-Gating authorization layer is configured to receive a requested digital action, and to determine, using a continuously evaluated and conditionally maintained authorization state, whether the requested action is permitted to execute, permitted to execute under modified constraints, or not permitted to execute. The system controls execution of actions in both pre-execution and mid-execution. The system includes components that receive action requests, acquire runtime context, evaluate authorization, assign execution permissions, mediate execution, and monitor outcomes. The system provides a graded and revocable execution permission state, which is continuously reassessed during execution, allowing for dynamic and adaptive control of action execution.
AI-Gating for the Diagnosis of Optic Neuropathy
This document relates to AI-guided systems and methods for the diagnosis and monitoring of optic neuropathies through the integration of Raman spectroscopy, artificial intelligence (AI), and optional adjunctive technologies. The document enables the molecular analysis of ocular tissues and fluids to detect neurodegenerative changes associated with conditions such as glaucomatous optic neuropathy, ischemic optic neuropathy, optic neuritis, and hereditary optic atrophies, including Leber’s Hereditary Optic Neuropathy (LHON). AI models are trained on validated Raman spectral biomarkers and are continuously updated through secure calibration pathways to improve predictive accuracy and reflect emerging clinical knowledge. The system supports both contact and non-contact acquisition, with AI-driven modules for spectral deconvolution, tissue-specific interpretation, and correlation with adjunctive data sources such as visual evoked potentials (VEP), optical coherence tomography (OCT), and visual field metrics. Embodiments enable real-time risk assessment, longitudinal disease tracking, and personalized care delivery.
AI-Gating for Safety-Critical Actions in Transporation
A system and method are disclosed for AI-Gated authorization of safety‑critical actions in transportation systems. The disclosed architecture introduces an explicit authorization layer that operates independently of perception and optimization modules and determines whether a proposed safety‑critical action is permitted at a given time. The authorization decision is based on predicted primary risk to protected entities and evaluation of secondary hazards that may arise from the proposed action under uncertainty. The system is particularly applicable to transportation environments in which mixed human‑controlled and automated agents interact, including roadway traffic systems involving vehicles, traffic control infrastructure, and vulnerable road users. By selectively permitting, delaying, or suppressing actions such as braking, steering, signal phase changes, or access control, the system improves safety, predictability, and explainability without modifying underlying sensing or control architectures. The disclosed approach supports fail‑safe degradation, auditability, and deployment across diverse transportation modalities.
AI-Gating for Microphysiological Systems
Without limiting the invention to any particular mechanism, the TM–SC interface may be viewed as a coupled, load-responsive epithelium–endothelium system in which transforming growth factor-β (TGFβ) signaling through Activin receptor-like kinases, particularly ALK5/TGFβR1, tends to promote barrier tightening and extracellular-matrix (ECM) accumulation, whereas vascular endothelial growth factor-C (VEGFC) signaling through VEGFR3/FLT4 in Schlemm’s canal supports a lymphatic-like endothelial identity associated with junctional patency and facilitated fluid entry into the canal. These axes operate under hydrodynamic load; pressure drop (ΔP) across the TM–membrane–SC stack and shear over the TM and along the canal are not merely boundary conditions but active inputs that modulate receptor availability, cytoskeletal tone, nuclear mechanotransduction, and therefore the net balance between tightening and loosening programs.
Dr. Michael Reynard’s academic research has been published in peer-reviewed medical publications . He holds patents for surgical instruments and lens implants for eye surgery.
Patents
A fiber optic integrated phacoemulsification system is disclosed comprising surgical handpieces for cataract surgery which incorporate fiber optic bundles that transmit visible light to enhance visualization by intraocular illumination. Patient safety is improved by the oblique lighting to the…
A disposable fiber optic sleeve for attachment at the forefront of a surgical instrument. The sleeve is an elongated tubular shape and incorporates multiple fiber optic bundles for transmission of visible light to enhance intraocular visualization. Additional bundles of optical fibers may provide…
A process and apparatus for removing cataractous lens tissue (22) in a human or animal eye and substitution of the lens with replacement material (48) utilizing an apparatus in the form of a surgical instrument (42). The process contains the steps of injecting a therapeutic photosensitive agent…
A multifocal phakic intraocular lens (10) designed to be placed in a phakic eye to correct various refractive disorders such as myopia, hyperopia, astigmatism and presbyopia. The lens (10) which can be positioned within the eye’s anterior chamber (62) or posterior chamber (63), consists of a…
Publications
Cataract Extraction in the Sympathizing Eye, Archives of Ophthalmology, 101:1701
Cryptococcal Intracerebral Mass Lesions, Annals of Internal Medicine, 94:382
Histocompatibility Antigens in Sympathetic Ophthalmia, American Journal of Ophthalmology, 95:216
Cavernous Sinus Syndrome Caused by Rhabdomyosarcoma, Annals of Ophthalmology, 15:94
Morphological Variation of Dalen-Fuchs Nodules in Sympathetic Ophthalmia, British Journal of Ophthalmology, 69:197
Two Cases of Uveal Metastasis from Breast Carcinoma in Men, American Journal of Ophthalmology, 95:208
Effect of Corticosteroid Treatment and Enucleation on the Visual Prognosis of Sympathetic Ophthalmia, American Journal of Ophthalmology, 96:290
Nd:YAG Laser Arteriotomy and Embolectomy for Central Retinal Artery Occlusion, American Journal of Ophthalmology, 137:196